Cryospots
Evidenz-Hub

Kryotherapie Studien — die wissenschaftliche Grundlage der Kältekammer.

Über 200 peer-reviewed Cryotherapy Studies aus 50+ Jahren klinischer und sportwissenschaftlicher Forschung — kuratiert, kategorisiert und kommentiert. Vom ersten Hokkaido-Protokoll Dr. Yamaguchis (1978) bis zu Meta-Analysen aus 2025.

208+
Studien
50
Jahre Forschung
8
Themen-Cluster

Was die Evidenz zeigt

Cryotherapy ist eine der am besten dokumentierten nicht-pharmakologischen Recovery-Methoden überhaupt. Mehr als ein halbes Jahrhundert klinischer und sportwissenschaftlicher Forschung — von Dr. Toshima Yamaguchis bahnbrechender Arbeit mit Rheuma-Patienten 1978 in Japan bis zu hochrangigen Meta-Analysen 2025 — bestätigt: Wer regelmäßig in eine Kältekammer geht, profitiert messbar.

Die Bandbreite der dokumentierten Wirkungen ist beeindruckend — und über die Studien hinweg konsistent. Whole-Body Cryotherapy reduziert Muskelkater (DOMS) nach intensivem Training, beschleunigt die Erholung zwischen Trainingseinheiten und senkt entzündungsfördernde Zytokine wie IL-6 und TNF-α nachweislich. Bei chronisch-entzündlichen Erkrankungen — rheumatoide Arthritis, Fibromyalgie, ankylosierende Spondylitis — zeigen Studien substanzielle Schmerzreduktion und Verbesserung der Lebensqualität. In der mentalen Gesundheit dokumentiert die Forschung positive Effekte auf Stimmung, Schlafqualität, Stressresilienz und Symptome leichter bis moderater Depressionen.

Wir bei Cryospots haben einen Vorteil gegenüber jedem einzelnen Cryo-Anbieter: wir verkaufen die Behandlung selbst nicht. Wir sind ein neutrales Verzeichnis. Das erlaubt uns, die Studienlage so darzustellen, wie sie ist — selbstbewusst, wo die Evidenz stark ist; nüchtern, wo Marketingclaims die Forschung überholen.

Evidenz nach Anwendungsbereich

Die acht zentralen Themen-Cluster der Cryotherapy-Forschung — klick durch zur gefilterten Studienliste.

Meistzitierte Studien

Die sechs einflussreichsten Cryotherapy-Arbeiten — gewichtet nach Zitationen und Aktualität.

471 Zitationen2004

The physiologic basis and clinical applications of cryotherapy and thermotherapy for the pain practitioner.

Cryotherapy reduces tissue metabolism and inflammation, while thermotherapy increases them, both providing significant pain relief with low side-effect profiles.

S. Nadler, K. Weingand, R. Kruse
Pain physician
372 Zitationen2010

Cryoablation: mechanism of action and devices.

Cryoablation causes tissue damage and death through direct and indirect mechanisms, with factors like cooling rate, target temperature, time at target temperature, and thawing rate influencing injury.

J. Erinjeri, T. Clark
Journal of vascular and interventional radiology : JVIRDOI ↗
328 ZitationenMeta-Analyse2018

An Evidence-Based Approach for Choosing Post-exercise Recovery Techniques to Reduce Markers of Muscle Damage, Soreness, Fatigue, and Inflammation: A Systematic Review With Meta-Analysis

Massage is the most effective method for reducing delayed onset muscle soreness and perceived fatigue after physical exercise, while compression techniques can effectively manage perceived fatigue.

O. Dupuy, W. Douzi, D. Theurot et al.
Frontiers in PhysiologyDOI ↗
372 Zitationen1996

Cryotherapy in sports medicine

Cryotherapy effectively treats acute soft tissue injuries, reduces pain, and speeds up recovery in sports medicine, with few complications or side-effects.

C. Swenson, L. Swärd, J. Karlsson
Scandinavian Journal of Medicine & Science in SportsDOI ↗
263 Zitationen2009

Experimental cryosurgery investigations in vivo.

Cryosurgery, using freezing temperatures to target targeted tissues, has advanced as a widely applied therapeutic option due to its effectiveness in cellular and tissue-related events.

A. Gage, J. Baust, J. Baust
CryobiologyDOI ↗
245 ZitationenLiteratur-Review2013

Water Immersion Recovery for Athletes: Effect on Exercise Performance and Practical Recommendations

Cold water immersion for 5-15 minutes is most effective for athletes, while both cold and warm water contrast therapy show promise for recovery, but the optimal technique remains unclear.

Nathan G. Versey, S. Halson, B. Dawson
Sports MedicineDOI ↗
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Alle Studien

30 von 208 Studien · Thema: Klinische Indikationen

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2004·471 Zit.

The physiologic basis and clinical applications of cryotherapy and thermotherapy for the pain practitioner.

Cryotherapy reduces tissue metabolism and inflammation, while thermotherapy increases them, both providing significant pain relief with low side-effect profiles.

S. Nadler, K. Weingand et al.
1996·372 Zit.

Cryotherapy in sports medicine

Cryotherapy effectively treats acute soft tissue injuries, reduces pain, and speeds up recovery in sports medicine, with few complications or side-effects.

C. Swenson, L. Swärd et al.DOI ↗
2010·227 Zit.

Whole-Body Cryotherapy in Athletes

Whole-body cryotherapy (WBC) is not harmful and does not induce negative effects in athletes, with potential benefits for pain relief and muscle recovery.

G. Banfi, G. Lombardi et al.DOI ↗
2021·88 Zit.

The cold truth: the role of cryotherapy in the treatment of injury and recovery from exercise

Cryotherapy reduces pain and soreness after injury or exercise, but its effectiveness depends on maintaining muscle temperature and applying it within the first few hours of structural damage.

S. Kwiecien, M. McHughDOI ↗
2022·63 Zit.Literatur-Review

The applications of cryoneurolysis for acute and chronic pain management

Cryoneurolysis, using extreme cold to targeted nerve tissue, provides prolonged pain relief without promoting motor blockade in both acute and chronic pain management settings.

Emily Biel, Edwin N. Aroke et al.DOI ↗
2020·57 Zit.Systematisches Review

Use of Cryotherapy for Managing Chronic Pain: An Evidence-Based Narrative

Cryotherapy shows promise in reducing chronic pain associated with various chronic diseases, offering a low-risk and easy treatment option for carefully selected patients.

Carol Garcia, Jay Karri et al.DOI ↗
2021·52 Zit.Randomisierte kontrollierte Studie

Cryotherapy for treatment of chronic rhinitis: 3‐month outcomes of a randomized, sham‐controlled trial

Cryotherapy is superior to a sham procedure for improving chronic rhinitis symptoms and patient quality of life at the 90-day follow-up.

Anthony G. Del Signore, J. Greene et al.DOI ↗
2023·29 Zit.Systematisches Review

Evaluating safety risks of whole-body cryotherapy/cryostimulation (WBC): a scoping review from an international consortium

Whole-body cryotherapy (WBC) has potential benefits for improving sleep quality, neuromuscular recovery, and chronic pain relief, with safety risks within acceptable limits when adhering to existing recommendations and guidelines.

Fabien D. Legrand, Benoit Dugué et al.DOI ↗
2022·29 Zit.Literatur-Review

Functional Impact of Post-exercise Cooling and Heating on Recovery and Training Adaptations: Application to Resistance, Endurance, and Sprint Exercise

Post-exercise cooling improves fatigue resistance in hot conditions after endurance exercise, but may impair sprint performance, while chronic cooling doesn't affect endurance training adaptations.

T. Chaillou, Viktorija Treigyte et al.DOI ↗
2022·21 Zit.

WHOLE-BODY CRYOSTIMULATION: A REHABILITATION BOOSTER

Whole-body cryostimulation (WBC) shows potential as an adjuvant therapy for various rehabilitation conditions, promoting recovery and restoring homeostasis.

P. Capodaglio, R. Cremascoli et al.DOI ↗
2024·14 Zit.Experimentelle Studie

Transbronchial cryoablation in peripheral lung parenchyma with a novel thin cryoprobe and initial clinical testing

Transbronchial cryoablation is a safe and feasible procedure for non-surgical peripheral stage IA lung cancer or pulmonary metastases, with potential for local therapy.

Chuanjia Gu, Haibin Yuan et al.DOI ↗
2024·13 Zit.Literatur-Review

A Narrative Review of Ultrasound-Guided and Landmark-based Percutaneous Cryoneurolysis for the Management of Acute and Chronic Pain

Ultrasound-guided and landmark-based cryoneurolysis is an effective method for managing acute and chronic pain, with potential applications in various conditions.

Rodney A. Gabriel, Erich Seng et al.DOI ↗
2023·12 Zit.Systematisches Review

Whole-body cryotherapy as a treatment for chronic medical conditions?

Whole-body cryotherapy shows potential as an adjuvant therapy for chronic inflammation in various medical conditions, including rheumatoid arthritis, obesity, and chronic brain disorders.

Hanna Tabisz, A. Modlińska et al.DOI ↗
2025·6 Zit.Experimentelle Studie

Muscle regeneration is improved by hot water immersion but unchanged by cold following a simulated musculoskeletal injury in humans

Hot water immersion improves muscle regeneration after an injury, while cold water immersion does not.

Valentin Dablainville, Adèle Mornas et al.DOI ↗
2024·8 Zit.Literatur-Review

Applications of Cryoneurolysis in Chronic Pain Management: a Review of the Current Literature

Cryoneurolysis shows potential in managing various chronic pain pathologies with a low complication rate, but more blinded, controlled, and prospective studies are needed to clarify its risks and advantages.

David L Chang, Benjamin D. Mirman et al.DOI ↗
2024·5 Zit.

Whole-body cryotherapy in orthopaedics: current concepts

Whole-body cryotherapy shows promise in improving bone health in athletes and providing relief for osteoarthritis and fibromyalgia, but more research is needed to establish standard protocols and understand long-term effects.

Madhan Jeyaraman, Filippo Migliorini et al.DOI ↗
2021·13 Zit.Experimentelle Studie

Efficacy of whole-body cryotherapy in the treatment of chronic low back pain: Quasi-experimental study.

Whole-body cryotherapy effectively reduces pain and disability in chronic low back pain patients, while also decreasing pro-inflammatory markers and increasing anti-inflammatory markers.

Ó. Salas-Fraire, J. A. Rivera-Perez et al.DOI ↗
2024·4 Zit.Experimentelle Studie

Whole-Body Cryostimulation: An Effective Complementary Treatment in Fibromyalgia? A Follow Up Study

Whole-body cryostimulation (WBC) as part of a rehabilitation program can provide stronger positive effects on improving key aspects of fibromyalgia, such as general well-being, pain level, and sleep quality, lasting 3-4 months.

Federica Verme, N. Majdič et al.DOI ↗
2025·1 Zit.Systematisches Review

Innovations in Chronic Pain Treatment: A Narrative Review on the Role of Cryoneurolysis

Cryoneurolysis is a safe technique for chronic pain management, particularly effective for selected neuropathic pain conditions, but more high-quality randomized controlled trials are needed to confirm its long-term efficacy and role.

A. Tinnirello, Maurizio Marchesini et al.DOI ↗
2025Systematisches Review

Optimizing Chronic Pain Treatment: A Summary of Infrequently Investigated Therapeutic Interventions for Modulating Pain.

Resistance training, fasting therapy, sauna therapy, and cryotherapy show promising results for chronic pain disorders, with potential mechanisms including central processes, peripheral mechanisms, neurotransmitters, nervous system activation, and mood enhancement.

Andrew J Ordille, Michael Sabia et al.
2025Systematisches Review

Effects of systemic and local cryotherapy on the course of neurodegenerative and autoimmune diseases - A Literature Review

Cryotherapy is a valuable adjunctive tool for treating chronic inflammatory diseases, but its use should be preceded by detailed clinical assessment and patient qualification.

Weronika Kalinowska, P. Kulasza et al.DOI ↗
2025Literatur-Review

The Comprehensive Evolution of Cryotherapy: A Review on Mechanisms, Applications and the Future of Cold Therapy from Sports Medicine to Metabolic Health

Cryotherapy effectively reduces pain and edema, improves recovery, and enhances mental well-being, but protocol standardization and long-term molecular and psychological effects require further research.

Cihangir AçıkDOI ↗
2025Systematisches Review

Cryotherapy following total knee replacement.

Cryotherapy may reduce blood loss and slightly improve pain after total knee replacement, but its effectiveness on transfusion rate, function, and adverse events remains uncertain.

Ashwin Aggarwal, S. Adie et al.DOI ↗
2025

Cryotherapy for the Management of Chronic Musculoskeletal Conditions: A Clinical Assessment of Pain and Function

Cold-air cryotherapy effectively reduces pain and improves range of motion in patients with chronic musculoskeletal conditions, making it a promising alternative for pain management.

Józef MrózDOI ↗
2023·2 Zit.Systematisches Review

Whole Body Cryotherapy in Sport and Physical Activity: A Narrative Review

Whole Body Cryotherapy (WBC) is a safe and effective tool in Sport Medicine, particularly for reducing post-exercise muscle soreness.

Paolo Mario Sarais, G. Alvarez Rey et al.DOI ↗
2022

H12: Campbell De Morgan: doctor, scientist, polymath

Cryotherapy, using low temperatures to destroy tissue, has evolved over the last 200 years, with advances in liquid nitrogen, solid carbon dioxide, and liquid oxygen, and its use expanded to treat various diseases and neoplasms.

A. Abdullah, L. O’Higgins et al.DOI ↗
2022

H11: A chilling history of cryotherapy

Cryotherapy, using low temperatures to destroy tissue, has evolved over the last 200 years, with advances in liquid nitrogen, solid carbon dioxide, and liquid oxygen, and its use expanded to treat various diseases and neoplasms.

A. Abdullah, L. O’Higgins et al.DOI ↗
2022

H13: Dermatological surgery through time: how sustainable are we now?

Cryotherapy has evolved over time to treat various skin conditions, with liquid nitrogen being the most effective and advancing technology in the 21st century.

A. Abdullah, L. O’Higgins et al.DOI ↗
2018

Cryotherapy: The Dry Benefits

Cryotherapy accelerates muscle recovery and improves overall wellbeing, with the cryosauna device providing a safe, healthy, and effective treatment for various conditions.

D. Draper, Brock RobertsDOI ↗
2015

An evaluation of the benefits of whole body cryotherapy treatment for sports recovery and injury repair

Whole Body Cryotherapy may promote recovery from strenuous exercise and enhance sports performance, but more research is needed to determine its timing, effectiveness, and potential negative effects on chronic adaptations to training.

A. Haq, W. Ribbans et al.

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