Cryospots
Evidenz-Hub

Kryotherapie Studien — die wissenschaftliche Grundlage der Kältekammer.

Über 200 peer-reviewed Cryotherapy Studies aus 50+ Jahren klinischer und sportwissenschaftlicher Forschung — kuratiert, kategorisiert und kommentiert. Vom ersten Hokkaido-Protokoll Dr. Yamaguchis (1978) bis zu Meta-Analysen aus 2025.

208+
Studien
50
Jahre Forschung
8
Themen-Cluster

Was die Evidenz zeigt

Cryotherapy ist eine der am besten dokumentierten nicht-pharmakologischen Recovery-Methoden überhaupt. Mehr als ein halbes Jahrhundert klinischer und sportwissenschaftlicher Forschung — von Dr. Toshima Yamaguchis bahnbrechender Arbeit mit Rheuma-Patienten 1978 in Japan bis zu hochrangigen Meta-Analysen 2025 — bestätigt: Wer regelmäßig in eine Kältekammer geht, profitiert messbar.

Die Bandbreite der dokumentierten Wirkungen ist beeindruckend — und über die Studien hinweg konsistent. Whole-Body Cryotherapy reduziert Muskelkater (DOMS) nach intensivem Training, beschleunigt die Erholung zwischen Trainingseinheiten und senkt entzündungsfördernde Zytokine wie IL-6 und TNF-α nachweislich. Bei chronisch-entzündlichen Erkrankungen — rheumatoide Arthritis, Fibromyalgie, ankylosierende Spondylitis — zeigen Studien substanzielle Schmerzreduktion und Verbesserung der Lebensqualität. In der mentalen Gesundheit dokumentiert die Forschung positive Effekte auf Stimmung, Schlafqualität, Stressresilienz und Symptome leichter bis moderater Depressionen.

Wir bei Cryospots haben einen Vorteil gegenüber jedem einzelnen Cryo-Anbieter: wir verkaufen die Behandlung selbst nicht. Wir sind ein neutrales Verzeichnis. Das erlaubt uns, die Studienlage so darzustellen, wie sie ist — selbstbewusst, wo die Evidenz stark ist; nüchtern, wo Marketingclaims die Forschung überholen.

Evidenz nach Anwendungsbereich

Die acht zentralen Themen-Cluster der Cryotherapy-Forschung — klick durch zur gefilterten Studienliste.

Meistzitierte Studien

Die sechs einflussreichsten Cryotherapy-Arbeiten — gewichtet nach Zitationen und Aktualität.

471 Zitationen2004

The physiologic basis and clinical applications of cryotherapy and thermotherapy for the pain practitioner.

Cryotherapy reduces tissue metabolism and inflammation, while thermotherapy increases them, both providing significant pain relief with low side-effect profiles.

S. Nadler, K. Weingand, R. Kruse
Pain physician
372 Zitationen2010

Cryoablation: mechanism of action and devices.

Cryoablation causes tissue damage and death through direct and indirect mechanisms, with factors like cooling rate, target temperature, time at target temperature, and thawing rate influencing injury.

J. Erinjeri, T. Clark
Journal of vascular and interventional radiology : JVIRDOI ↗
328 ZitationenMeta-Analyse2018

An Evidence-Based Approach for Choosing Post-exercise Recovery Techniques to Reduce Markers of Muscle Damage, Soreness, Fatigue, and Inflammation: A Systematic Review With Meta-Analysis

Massage is the most effective method for reducing delayed onset muscle soreness and perceived fatigue after physical exercise, while compression techniques can effectively manage perceived fatigue.

O. Dupuy, W. Douzi, D. Theurot et al.
Frontiers in PhysiologyDOI ↗
372 Zitationen1996

Cryotherapy in sports medicine

Cryotherapy effectively treats acute soft tissue injuries, reduces pain, and speeds up recovery in sports medicine, with few complications or side-effects.

C. Swenson, L. Swärd, J. Karlsson
Scandinavian Journal of Medicine & Science in SportsDOI ↗
263 Zitationen2009

Experimental cryosurgery investigations in vivo.

Cryosurgery, using freezing temperatures to target targeted tissues, has advanced as a widely applied therapeutic option due to its effectiveness in cellular and tissue-related events.

A. Gage, J. Baust, J. Baust
CryobiologyDOI ↗
245 ZitationenLiteratur-Review2013

Water Immersion Recovery for Athletes: Effect on Exercise Performance and Practical Recommendations

Cold water immersion for 5-15 minutes is most effective for athletes, while both cold and warm water contrast therapy show promise for recovery, but the optimal technique remains unclear.

Nathan G. Versey, S. Halson, B. Dawson
Sports MedicineDOI ↗
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Alle Studien

62 von 208 Studien · Thema: Physiologie & Mechanismus

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2004·471 Zit.

The physiologic basis and clinical applications of cryotherapy and thermotherapy for the pain practitioner.

Cryotherapy reduces tissue metabolism and inflammation, while thermotherapy increases them, both providing significant pain relief with low side-effect profiles.

S. Nadler, K. Weingand et al.
2010·372 Zit.

Cryoablation: mechanism of action and devices.

Cryoablation causes tissue damage and death through direct and indirect mechanisms, with factors like cooling rate, target temperature, time at target temperature, and thawing rate influencing injury.

J. Erinjeri, T. ClarkDOI ↗
1996·372 Zit.

Cryotherapy in sports medicine

Cryotherapy effectively treats acute soft tissue injuries, reduces pain, and speeds up recovery in sports medicine, with few complications or side-effects.

C. Swenson, L. Swärd et al.DOI ↗
2013·245 Zit.Literatur-Review

Water Immersion Recovery for Athletes: Effect on Exercise Performance and Practical Recommendations

Cold water immersion for 5-15 minutes is most effective for athletes, while both cold and warm water contrast therapy show promise for recovery, but the optimal technique remains unclear.

Nathan G. Versey, S. Halson et al.DOI ↗
1986·314 Zit.

The Use of Cryotherapy in Sports Injuries

Cryotherapy positively impacts pain reduction and injury recovery in athletes, with varying effects on temperature and blood flow.

R. Meeusen, P. LievensDOI ↗
2010·227 Zit.

Whole-Body Cryotherapy in Athletes

Whole-body cryotherapy (WBC) is not harmful and does not induce negative effects in athletes, with potential benefits for pain relief and muscle recovery.

G. Banfi, G. Lombardi et al.DOI ↗
2013·171 Zit.

Cold-water immersion and other forms of cryotherapy: physiological changes potentially affecting recovery from high-intensity exercise

Cryotherapy, involving cold-water immersion and other forms, may speed recovery from high-intensity exercise by reducing tissue temperature and affecting blood flow, cell swelling, metabolism, and neural conductance velocity.

Gillian E. White, Greg D. WellsDOI ↗
2017·145 Zit.Literatur-Review

Whole-Body Cryotherapy in Athletes: From Therapy to Stimulation. An Updated Review of the Literature

Whole-body cryotherapy is a widely used sports medicine treatment that improves pain, soreness, stress, and post-exercise recovery, with potential applications in metabolic diseases like obesity and type 2 diabetes.

G. Lombardi, E. Ziemann et al.DOI ↗
2016·137 Zit.Literatur-Review

Whole- and partial-body cryostimulation/cryotherapy: Current technologies and practical applications.

Whole- and partial-body cryotherapy offer physiological and psychological benefits, but current protocols and technologies need improvement for optimal treatment outcomes.

R. Bouzigon, F. Grappe et al.DOI ↗
2019·127 Zit.Literatur-Review

Cryoablation and immunotherapy: an overview of evidence on its synergy

Cryoablation and immunotherapy show potential synergistic effects in cancer treatment, potentially enhancing the effectiveness of both therapies.

B. M. Aarts, B. M. Aarts et al.DOI ↗
2022·63 Zit.Literatur-Review

The applications of cryoneurolysis for acute and chronic pain management

Cryoneurolysis, using extreme cold to targeted nerve tissue, provides prolonged pain relief without promoting motor blockade in both acute and chronic pain management settings.

Emily Biel, Edwin N. Aroke et al.DOI ↗
2013·86 Zit.

Catheter Cryoablation: Biology and Clinical Uses

Cryoablation, using high-temperature temperatures to treat medical disorders, has a long history of safe and effective use in medicine, with potential advantages over standard radiofrequency catheter ablation in cardiac electrophysiology.

J. Andrade, P. Khairy et al.DOI ↗
2022·57 Zit.

Cold for centuries: a brief history of cryotherapies to improve health, injury and post-exercise recovery

Cryotherapies, using ice, cold-water, and cold air, have been used for centuries to improve health, injury recovery, and post-exercise recovery, with benefits including reduced pain and improved well-being.

R. Allan, J. Malone et al.DOI ↗
2017·68 Zit.Literatur-Review

Cold-Water Immersion for Athletic Recovery: One Size Does Not Fit All.

Cold-water immersion for athletic recovery may vary in effectiveness based on individual characteristics, water-immersion protocol, and exercise type, requiring further research to optimize prescription.

Jessica M Stephens, S. Halson et al.DOI ↗
2023·47 Zit.

Progress in the cryoablation and cryoimmunotherapy for tumor

Cryoablation technology effectively treats tumors and activates the immune system, potentially leading to tumor regression and distant metastasis.

Zenan Chen, Liangliang Meng et al.DOI ↗
2018·49 Zit.Randomisierte kontrollierte Studie

Cold‐water or partial‐body cryotherapy? Comparison of physiological responses and recovery following muscle damage

Cold-water immersion has a greater impact on physiological responses than partial-body cryotherapy, but both treatments result in similar recovery profiles over a 72-hour follow-up period.

E. Hohenauer, E. Hohenauer et al.DOI ↗
2019·42 Zit.Randomisierte kontrollierte Studie

Partial‐body cryotherapy (−135°C) and cold‐water immersion (10°C) after muscle damage in females

Cold-water immersion and partial-body cryotherapy effectively reduce delayed onset muscle soreness in females after exercise-induced muscle damage, but have no effect on functional measures or swelling.

E. Hohenauer, J. Costello et al.DOI ↗
2023·29 Zit.Systematisches Review

Evaluating safety risks of whole-body cryotherapy/cryostimulation (WBC): a scoping review from an international consortium

Whole-body cryotherapy (WBC) has potential benefits for improving sleep quality, neuromuscular recovery, and chronic pain relief, with safety risks within acceptable limits when adhering to existing recommendations and guidelines.

Fabien D. Legrand, Benoit Dugué et al.DOI ↗
2021·29 Zit.Literatur-Review

Passive Recovery Strategies after Exercise: A Narrative Literature Review of the Current Evidence

Passive recovery techniques, such as compression garments, cold water immersion, partial body cryotherapy, hyperbaric oxygen, and vibratory therapies, show improved athlete recovery and faster return to peak performance.

Michael-Flynn L. Cullen, G. Casazza et al.DOI ↗
2021·29 Zit.

Post-exercise Recovery: Cooling and Heating, a Periodized Approach

Athletes need to optimize their recovery process to reduce fatigue, injury risk, and illness, while maintaining performance and minimizing financial implications.

R. ThorpeDOI ↗
2006·71 Zit.

Cryotherapy for treatment of oral lesions.

Cryotherapy is a non-surgical, non-irritating treatment for oral lesions, with minimal scarring and is particularly useful for patients who cannot undergo surgery due to age or medical history.

Claude S. Farah, N. SavageDOI ↗
2024·18 Zit.Literatur-Review

Cryotherapy for treating soft tissue injuries in sport medicine: a critical review

Cryotherapy may reduce pain in the first 6 hours after an injury, but its effectiveness beyond 12 hours is uncertain due to animal studies suggesting it may interfere with tissue healing and regeneration.

S. Racinais, Valentin Dablainville et al.DOI ↗
2022·21 Zit.

WHOLE-BODY CRYOSTIMULATION: A REHABILITATION BOOSTER

Whole-body cryostimulation (WBC) shows potential as an adjuvant therapy for various rehabilitation conditions, promoting recovery and restoring homeostasis.

P. Capodaglio, R. Cremascoli et al.DOI ↗
2024·13 Zit.

Modern cancer therapy: cryoablation meets immune checkpoint blockade

Cryoablation combined with immune checkpoint blockers shows promising synergy and is safe and effective in treating cancer.

Qi Liu, Chunyang Zhang et al.DOI ↗
2023·12 Zit.Systematisches Review

Whole-body cryotherapy as a treatment for chronic medical conditions?

Whole-body cryotherapy shows potential as an adjuvant therapy for chronic inflammation in various medical conditions, including rheumatoid arthritis, obesity, and chronic brain disorders.

Hanna Tabisz, A. Modlińska et al.DOI ↗
2024·9 Zit.Literatur-Review

Percutaneous cryoablation in soft tissue tumor management: an educational review

Percutaneous cryoablation (PCA) is a promising, minimally invasive alternative for managing soft tissue tumors, offering pain reduction, tumor size decrease, and enhanced patient outcomes.

S. Bodard, Ruben Geevarghese et al.DOI ↗
2024·9 Zit.Systematisches Review

Whole-Body Cryostimulation in Multiple Sclerosis: A Scoping Review

Whole-body cryostimulation may improve functional status, mood, anxiety, and fatigue in MS patients without causing adverse effects.

Angelo Alito, J. Fontana et al.DOI ↗
2025·6 Zit.Experimentelle Studie

Muscle regeneration is improved by hot water immersion but unchanged by cold following a simulated musculoskeletal injury in humans

Hot water immersion improves muscle regeneration after an injury, while cold water immersion does not.

Valentin Dablainville, Adèle Mornas et al.DOI ↗
2025·5 Zit.Systematisches Review

Mechanisms and parameters of cryotherapy intervention for early postoperative swelling following total knee arthroplasty: A scoping review

Cryotherapy may reduce swelling after total knee arthroplasty by reducing haemorrhage and inflammation, but its effectiveness is low and its parameters are not standardized.

Lin Yang, Yi-fang Zhan et al.DOI ↗
2019·22 Zit.

Whole-Body Cryotherapy: Potential to Enhance Athlete Preparation for Competition?

Whole-body cryotherapy may enhance an athlete's competition readiness and recovery by promoting hormonal, anti-inflammatory, and psychological responses in the hours before competition.

Emily M Partridge, J. Cooke et al.DOI ↗
2025·3 Zit.Literatur-Review

Cryoablation for breast cancer: a narrative review of advances, clinical applications, and future challenges

Cryoablation is a promising alternative to traditional surgical methods for treating early-stage, advanced, and inoperable breast cancer, with potential for enhancing anti-tumor immune responses and preventing tumor recurrence.

Manchen Yang, Baosan Han et al.DOI ↗
2024·5 Zit.

Whole-body cryotherapy in orthopaedics: current concepts

Whole-body cryotherapy shows promise in improving bone health in athletes and providing relief for osteoarthritis and fibromyalgia, but more research is needed to establish standard protocols and understand long-term effects.

Madhan Jeyaraman, Filippo Migliorini et al.DOI ↗
2022·10 Zit.Experimentelle Studie

The Comparative Effect of Different Timings of Whole Body Cryotherapy Treatment With Cold Water Immersion for Post-Exercise Recovery

Whole Body Cryotherapy within an hour of exercise may be preferable for muscle strength recovery, but it is no more effective than cold water immersion for post-exercise recovery.

A. Haq, W. Ribbans et al.DOI ↗
2025·1 Zit.Systematisches Review

Cryotherapy and Whole Body Cooling: A Critical Review of Physiological Impacts on Elite Athletes

Cryotherapy aids acute recovery and strength retention in elite athletes, but requires strict safety protocols and individualized approaches.

Wojciech Tokarczyk, Karol Demel et al.DOI ↗
2025·1 Zit.Literatur-Review

Exploring the role of cryotherapy in plastic surgery: mechanisms, applications, and future directions

Cryotherapy shows promise in managing postoperative pain and reducing swelling in plastic surgery, offering a low-risk, high-reward option for improving patient care.

Hatan Mortada, Raghad AlKhashan et al.DOI ↗
2022·9 Zit.Systematisches Review

Different Cryotherapy Modalities Demonstrate Similar Effects on Muscle Performance, Soreness, and Damage in Healthy Individuals and Athletes: A Systematic Review with Metanalysis

Whole-body and partial-body cryotherapy both have similar effects on muscle performance, soreness, and markers of muscle damage after exercise-induced damage.

K. Azevedo, Júlia Aguillar Ivo Bastos et al.DOI ↗
2025Systematisches Review

Optimizing Chronic Pain Treatment: A Summary of Infrequently Investigated Therapeutic Interventions for Modulating Pain.

Resistance training, fasting therapy, sauna therapy, and cryotherapy show promising results for chronic pain disorders, with potential mechanisms including central processes, peripheral mechanisms, neurotransmitters, nervous system activation, and mood enhancement.

Andrew J Ordille, Michael Sabia et al.
2025Literatur-Review

Local Cryotherapy in Traumatology and Orthopedics: A Review of Current Approaches and Potential Clinical Use

Local cryotherapy shows promise in treating musculoskeletal diseases and rehabilitating injuries, but more research is needed to optimize treatment regimens and develop personalized protocols.

A. Pushkarev, N. Saakyan et al.DOI ↗
2025Systematisches Review

Effects of systemic and local cryotherapy on the course of neurodegenerative and autoimmune diseases - A Literature Review

Cryotherapy is a valuable adjunctive tool for treating chronic inflammatory diseases, but its use should be preceded by detailed clinical assessment and patient qualification.

Weronika Kalinowska, P. Kulasza et al.DOI ↗
2025Literatur-Review

The Comprehensive Evolution of Cryotherapy: A Review on Mechanisms, Applications and the Future of Cold Therapy from Sports Medicine to Metabolic Health

Cryotherapy effectively reduces pain and edema, improves recovery, and enhances mental well-being, but protocol standardization and long-term molecular and psychological effects require further research.

Cihangir AçıkDOI ↗
2025

Cryosurgery in oral lesions

Cryosurgery, using liquid nitrogen, is an effective alternative therapy for various oral lesions, benefiting from its versatility in treating benign, precancerous, and malignant diseases.

Eleni Georgakopoulou, Panagiota Loumou et al.DOI ↗
2025Literatur-Review

The effects of cryotherapy on proprioception, indices of muscle damage and on intramuscular, skin and core temperature

Whole Body Cryotherapy (WBC) does not reduce knee Joint Position Sense (JPS), muscle force, or force proprioception, and is ineffective in alleviating muscle soreness or enhancing muscle force recovery 24 hours after eccentric exercise.

J. Costello
2025Systematisches Review

Hydrotherapy Interventions for Muscle Recovery in Athletes: A Narrative Review

Hydrotherapy interventions, such as cold water immersion and contrast water therapy, effectively reduce muscle edema, inflammation, and pain, leading to improved muscle function and performance in athletes.

Nanjeshgowda H LDOI ↗
2025Randomisierte kontrollierte Studie

Effect of pneumatic and cold compression on muscle performance and recovery in combat sports athletes

Pneumatic and cold compression therapies accelerate recovery in combat athletes by improving blood flow and muscle elasticity, potentially improving performance and reducing injury risk.

R. Trybulski, Sebastian Klich et al.DOI ↗
2025Meta-Analyse

Fatigue Recovery and Exercise Performance after Contrast Water Therapy- Meta-analysis

Contrast Water Therapy (CWT) can reduce perceived muscle soreness and fatigue, but its impact on objective performance is limited.

Feiyan Xiao, Jiao Lu et al.DOI ↗
2022·6 Zit.Systematisches Review

Cryotherapy in Anterior Cruciate Ligamentoplasty Pain: A Scoping Review

Cryotherapy effectively reduces pain intensity in the immediate postoperative period of ACL reconstruction, with cryocompression being superior to conventional cryotherapy.

Isabela Eising Mendes, J. C. Ribeiro Filho et al.DOI ↗
2024Systematisches Review

CRYOTHERAPY IN THE FIELD OF ENDODONTICS: A LITERATURE REVIEW

Cryotherapy can effectively control postoperative pain and inflammation in endodontics, reducing nerve conduction velocity and promoting local anti-inflammation.

Amena Al Bast, R. AbiadDOI ↗
2024Randomisierte kontrollierte Studie

Effect of whole-body cryotherapy on recovery after high-intensity training in elite rowers

A single session of whole-body cryotherapy effectively accelerates blood lactate elimination after high-intensity training, but does not significantly change rowing performance or physiological parameters.

Tao Huang, Linfei Dan et al.DOI ↗
2023·2 Zit.Systematisches Review

Cryotherapy in Postoperative Shoulder Surgery: A Systematic Review

Cryotherapy is generally effective in reducing postoperative shoulder pain, but more high-quality studies are needed to confirm its effectiveness in shoulder rehabilitation and its impact on functionality and range of motion.

Anna Julia Brittes Gabiatti, Geovana Bressiani Hillesheim et al.DOI ↗
2021·6 Zit.Systematisches Review

Cryosurgery and physical medicine n treatment of cancer

Cryosurgery combined with other physical medicine techniques can enhance the effectiveness of treating cancer patients by maximizing the potential for exposure of biological tissues to low temperatures.

M. Chyzh, I. Belochkina et al.DOI ↗
2023Meta-Analyse

Effects of contrast therapy on post-exercise recovery: an updated systematic review and meta-analysis

Contrast therapy, which involves alternating hot and cold temperatures, effectively aids post-exercise recovery and enhances physical performance.

Hyun-Seok Choi, I. Cho et al.DOI ↗
2021·5 Zit.Systematisches Review

Pre-Exercise Whole- or Partial-Body Cryotherapy Exposure to Improve Physical Performance: A Systematic Review

Pre-exercise whole- or partial-body cryotherapy exposure has unclear potential for improving physical performance, with limited good-quality research and lack of standardization of protocols.

Emily M Partridge, J. Cooke et al.DOI ↗
2021·3 Zit.Randomisierte kontrollierte Studie

Effects of contemporary cryo-compression on post-training performance in elite academy footballers

Cryotherapy reduces countermovement jump performance in elite male footballers after a fatiguing training session, but not in those receiving passive recovery.

J. Alexander, Jane E Keegan et al.DOI ↗
2021·2 Zit.

Cryotherapy in sport: a warm reception for the translation of evidence into applied practice

Cryotherapy's role in sport injury management is unclear, and future study designs should reflect current demands and individual responses for improved evidence translation.

J. Alexander, Dr Robert Allan et al.DOI ↗
2020·1 Zit.

Application of the cryodenervation method in palliative medicine

Cryodestruction is a safe and effective method for treating pain in palliative medicine, especially in difficult-to-relieve cases.

P. Jakubów, U. Kosciuczuk et al.DOI ↗
2018·4 Zit.Literatur-Review

Enhancing the Physiology and Effectiveness of Whole-Body Cryotherapy Treatment for Sports Recovery by Establishing an Optimum Protocol: A Review of Recent Perspectives

Optimum Whole-Body Cryotherapy treatment for sports recovery should be applied within 60 minutes of exercise, with young, lean males benefiting more, and adjustments in temperature, duration, and frequency.

A. Haq, A. Baross et al.DOI ↗
2018Literatur-Review

CRYOSURGERY DEVELOPING

Cryosurgery has developed since the 19th century, but its effectiveness in various medical fields is limited by a lack of understanding of tissue damage mechanisms and the need for better temperature control.

S. Artemev, Z. Radzhabova et al.DOI ↗
2018

Cryotherapy: The Dry Benefits

Cryotherapy accelerates muscle recovery and improves overall wellbeing, with the cryosauna device providing a safe, healthy, and effective treatment for various conditions.

D. Draper, Brock RobertsDOI ↗
2018

PO-228 Effects of Different Cryotherapy Models on Timing Sequence Recovery of Exercise Induced Muscle Damage in Middle and Long Distance Runners

Whole body cryotherapy (cryostimulation) has the best recovery effects for exercise-induced muscle damage in middle and long distance runners compared to cold water immersion and contrast water therapy.

Chaoyi Qu, Minxiao Xu et al.DOI ↗
2015

An evaluation of the benefits of whole body cryotherapy treatment for sports recovery and injury repair

Whole Body Cryotherapy may promote recovery from strenuous exercise and enhance sports performance, but more research is needed to determine its timing, effectiveness, and potential negative effects on chronic adaptations to training.

A. Haq, W. Ribbans et al.
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